Ctrl + Shift + B   Show or hide the favorites bar  

Alt + Shift + B     Set focus on the first item in the favorites bar  

Ctrl + D  Save the current tab as a favorite  

Ctrl + Shift + D  Save all open tabs as favorites in a new folder

Ctrl + Shift + E Open search in sidebar

Alt + D Select the URL in the address bar to edit

Ctrl + E Open a search query in the address bar

Alt + E Open the Settings and more  menu

Ctrl + F Open find on page

Alt + F Open the Settings and more  menu

Ctrl + G Jump to the next result for find on page

Ctrl + Shift + G Jump to the previous result for find on page

Ctrl + H Open History 

Ctrl + Shift + I Open Developer Tools

Alt + Shift + I Open the Send feedback dialog

Ctrl + J Open Downloads 

Ctrl + K Open a search query in the address bar

Ctrl + Shift + K Duplicate the current tab

Ctrl + L Select the URL in the address bar to edit

Ctrl + Shift + L Paste and search or Paste and go (if it's a URL)

Ctrl + M Mute the current tab (toggle)

Ctrl + Shift + M Sign in as a different user or browse as a Guest

Ctrl + N Open a new window

Ctrl + Shift + N Open a new InPrivate window

Ctrl + O Open a file from your computer in Edge

Ctrl + Shift + O Open Favorites 

Ctrl + P Print the current page

Ctrl + Shift + P Print using the system dialog

Ctrl + R Reload the current page

Ctrl + Shift + R Reload the current page, ignoring cached content

Ctrl + S Save the current page

Ctrl + T Open a new tab and switch to it

Ctrl + Shift + T Reopen the last closed tab, and switch to it

Alt + Shift + T Set focus on the first item in the app bar toolbar

Ctrl + U View source

Ctrl + Shift + U Start or stop Read Aloud

Ctrl + Shift + V Paste without formatting

Ctrl + W Close the current tab

Ctrl + Shift + W Close the current window

Ctrl + Shift + Y Open Collections

Ctrl + 0 (zero) Reset page zoom level

Ctrl + 1, 2, ... 8 Switch to a specific tab

Ctrl + 9 Switch to the last tab

Ctrl + Enter Add www. to the beginning and .com to the end of text typed in the address bar

Ctrl + Tab Switch to the next tab

Ctrl + Shift + Tab Switch to the previous tab

Ctrl + Plus (+) Zoom in

Ctrl + Minus (-) Zoom out

Ctrl + \ (in a PDF) Toggle PDF between fit to page / fit to width

Ctrl + [ (in a PDF) Rotate PDF counter-clockwise 90*

Ctrl + ] (in a PDF) Rotate PDF clockwise 90*

Ctrl + Shift + Delete Open clear browsing data options

Alt Set focus on the Settings and more  button

Alt + Left arrow Go back

Alt + Right arrow Go forward

Alt + Home Open your home page in the current tab

Alt + F4 Close the current window

F1 Open Help

F3 Find in the current tab

F4 Select the URL in the address bar

Ctrl + F4 Close the current tab

F5 Reload the current tab

Shift + F5 Reload the current tab, ignoring cached content

F6 Move focus to next pane

Shift + F6 Move focus to previous pane

Ctrl + F6 Move focus to the web content pane

F7 Turn caret browsing on or off

F9 Enter or exit Immersive Reader

F10 Set focus on the Settings and more  button

F10 + Enter Open Setting and more  menu

Shift + F10 Open context menu

F11 Enter full screen (toggle)

F12 Open Developer Tools

Esc Stop loading page; close dialog or pop-up

Spacebar Scroll down webpage, one screen at a time

Shift + Spacebar Scroll up webpage, one screen at a time

PgDn Scroll down webpage, one screen at a time

Ctrl + PgDn Switch to the next tab

PgUp Scroll up webpage, one screen at a time

Ctrl + PgUp Switch to the previous tab

Home Go to the top of the page, Move keyboard focus to first item of pane

End Go to the bottom of the page, Move keyboard focus to last item of pane

Tab Go to next tab stop

Shift + Tab Go to previous tab stop